abstract：BACKGROUND:Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of therapy in African children. METHODS:The factors contributing to delay in parasite clearance, def...

journal_title：Malaria journal

authors： Sowunmi A,Adewoye EO,Gbotsho GO,Happi CT,Sijuade A,Folarin OA,Okuboyejo TM,Michael OS

更新日期：2010-02-15 00:00:00

abstract：BACKGROUND:Malaria remains the most important public health problem in tropical and subtropical areas. Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs...

journal_title：Malaria journal

authors： Yewhalaw D,Kassahun W,Woldemichael K,Tushune K,Sudaker M,Kaba D,Duchateau L,Van Bortel W,Speybroeck N

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:With the increase in use of point-of-care diagnostic tests for malaria and other diseases comes the necessity of storing the diagnostic kits and the drugs required for subsequent management, in remote areas, where temperatures are high and electricity supply is unreliable or unavailable. METHODS:To address ...

journal_title：Malaria journal

authors： Chanthap L,Ariey F,Socheat D,Tsuyuoka R,Bell D

更新日期：2010-01-23 00:00:00

abstract：BACKGROUND:Most malaria rapid diagnostic tests (RDTs) use HRP2 detection, including Paracheck-Pf(R), but their utility is limited by persistent false positivity after treatment. PLDH-based tests become negative more quickly, but sensitivity has been reported below the recommended standard of 90%. A new pLDH test, CareS...

journal_title：Malaria journal

authors： Gerstl S,Dunkley S,Mukhtar A,De Smet M,Baker S,Maikere J

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:Interest in the use of fungal entomopathogens against malaria vectors is growing. Fungal spores infect insects via the cuticle and can be applied directly on the insect to evaluate infectivity. For flying insects such as mosquitoes, however, application of fungal suspensions on resting surfaces is more reali...

journal_title：Malaria journal

authors： Farenhorst M,Knols BG

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:Molecular genotyping is performed in anti-malarial trials to determine whether recurrent parasitaemia after therapy represents a recrudescence (treatment failure) or new infection. The use of capillary instead of agarose gel electrophoresis for genotyping offers technical advantages, but it is unclear whethe...

journal_title：Malaria journal

authors： Gupta V,Dorsey G,Hubbard AE,Rosenthal PJ,Greenhouse B

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:The objective of this project was to achieve high, sustainable levels of net coverage in a village in rural Tanzania by combining free distribution of long-lasting insecticide-impregnated nets (LLINs) with community-tailored education. In Tanzania, malaria is the leading cause of morbidity and mortality. Alt...

journal_title：Malaria journal

authors： Widmar M,Nagel CJ,Ho DY,Benziger PW,Hennig N

更新日期：2009-12-31 00:00:00

abstract：BACKGROUND:Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multi-valent vaccine formulation. This report describes the immunological characterization of linear and cycliz...

journal_title：Malaria journal

authors： Tamborrini M,Mueller MS,Stoffel SA,Westerfeld N,Vogel D,Boato F,Zurbriggen R,Robinson JA,Pluschke G

更新日期：2009-12-30 00:00:00

abstract：BACKGROUND:The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported to inhibit adhesion. Since the anti-malarial drug chloroquine accum...

journal_title：Malaria journal

authors： Bhattacharyya S,Solakyildirim K,Zhang Z,Linhardt RJ,Tobacman JK

更新日期：2009-12-17 00:00:00

abstract：BACKGROUND:Effective and timely treatment is an essential aspect of malaria control, but remains a challenge in many parts of sub-Saharan Africa. The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso. METHODS:In February/March 2006, a survey was...

journal_title：Malaria journal

authors： Tipke M,Louis VR,Yé M,De Allegri M,Beiersmann C,Sié A,Mueller O,Jahn A

更新日期：2009-11-24 00:00:00

abstract：:The sterile insect technique (SIT) has been shown to be an effective and sustainable genetic approach to control populations of selected major pest insects, when part of area-wide integrated pest management (AW-IPM) programmes. The technique introduces genetic sterility in females of the target population in the field...

journal_title：Malaria journal

authors： Robinson AS,Knols BG,Voigt G,Hendrichs J

更新日期：2009-11-16 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:The diversity of genotyping markers of Plasmodium falciparum depends on transmission intensity. It has been reported that the diversity of the merozoite surface protein 2 (msp2) is greater in areas of high compared to low endemicity, however, results for msp1 were inconsistent. These previous reports relied ...

journal_title：Malaria journal

authors： Schoepflin S,Valsangiacomo F,Lin E,Kiniboro B,Mueller I,Felger I

更新日期：2009-10-30 00:00:00

abstract：BACKGROUND:In the Tanga District of coastal Tanzania, malaria is one of the primary causes of mortality for children under the age of five. While some children are treated with malaria medications in biomedical facilities, as the World Health Organization recommends, others receive home-care or treatment from tradition...

journal_title：Malaria journal

authors： Foster D,Vilendrer S

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). METHODS:In Dawei, southern Myanmar, three pLDH based RDTs (CareStart Malaria pLDH...

journal_title：Malaria journal

authors： Ashley EA,Touabi M,Ahrer M,Hutagalung R,Htun K,Luchavez J,Dureza C,Proux S,Leimanis M,Lwin MM,Koscalova A,Comte E,Hamade P,Page AL,Nosten F,Guerin PJ

更新日期：2009-10-27 00:00:00

abstract：BACKGROUND:Artesunate plus sulphadoxine-pyrimethamine is one of the four artemisinin-based combination therapies currently recommended by WHO as first-line treatment for falciparum malaria. Sulphadoxine-pyrimethamine is also used for intermittent preventive treatment for malaria in pregnancy. Drug use patterns and drug...

journal_title：Malaria journal

authors： Gbotosho GO,Happi CT,Sijuade AO,Sowunmi A,Oduola AM

更新日期：2009-10-24 00:00:00

abstract：:Artemisinin, from which the artemether component of Coartem (artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy. Artemisinin was first identified by Chinese researchers as the active anti-malarial cons...

journal_title：Malaria journal

authors： Premji ZG

更新日期：2009-10-12 00:00:00

abstract：BACKGROUND:Autoregressive regression coefficients for Anopheles arabiensis aquatic habitat models are usually assessed using global error techniques and are reported as error covariance matrices. A global statistic, however, will summarize error estimates from multiple habitat locations. This makes it difficult to iden...

journal_title：Malaria journal

authors： Jacob BG,Griffith DA,Muturi EJ,Caamano EX,Githure JI,Novak RJ

更新日期：2009-09-21 00:00:00

abstract：:The global health community is interested in the health impact of the billions of dollars invested to fight malaria in Africa. A recent publication used trends in malaria cases and deaths based on health facility records to evaluate the impact of malaria control efforts in Rwanda and Ethiopia. Although the authors dem...

journal_title：Malaria journal

authors： Rowe AK,Kachur SP,Yoon SS,Lynch M,Slutsker L,Steketee RW

更新日期：2009-09-03 00:00:00

abstract：BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...

journal_title：Malaria journal

authors： Hombhanje FW,Linge D,Saweri A,Kuanch C,Jones R,Toraso S,Geita J,Masta A,Kevau I,Hiawalyer G,Sapuri M

更新日期：2009-08-12 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:Very few data on anti-malarial efficacy are available from the Democratic Republic of Congo (DRC). DRC changed its anti-malarial treatment policy to amodiaquine (AQ) and artesunate (AS) in 2005. METHODS:The results of two in vivo efficacy studies, which tested AQ and sulphadoxine-pyrimethamine (SP) monother...

journal_title：Malaria journal

authors： Bonnet M,Broek Iv,van Herp M,Urrutia PP,van Overmeir C,Kyomuhendo J,Ndosimao CN,Ashley E,Guthmann JP

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS:Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria across 128 counties were assembled for Yunnan, a province of Chi...

journal_title：Malaria journal

authors： Clements AC,Barnett AG,Cheng ZW,Snow RW,Zhou HN

更新日期：2009-07-31 00:00:00

abstract：BACKGROUND:The use of insecticide-treated nets (ITN) is an important tool in the Roll Back Malaria (RBM) strategy. For ITNs to be effective they need to be used correctly. Previous studies have shown that many factors, such as wealth, access to health care, education, ethnicity and gender, determine the ownership and u...

journal_title：Malaria journal

authors： Toé LP,Skovmand O,Dabiré KR,Diabaté A,Diallo Y,Guiguemdé TR,Doannio JM,Akogbeto M,Baldet T,Gruénais ME

更新日期：2009-07-29 00:00:00

abstract：BACKGROUND:Convulsions is one of the key signs of severe malaria among children under five years of age, potentially leading to serious complications or death. Several studies of care-seeking behaviour have revealed that local illness concepts linked to convulsions (referred to as degedege in Tanzanian Kiswahili) calle...

journal_title：Malaria journal

authors： Dillip A,Hetzel MW,Gosoniu D,Kessy F,Lengeler C,Mayumana I,Mshana C,Mshinda H,Schulze A,Makemba A,Pfeiffer C,Weiss MG,Obrist B

更新日期：2009-06-29 00:00:00

abstract：BACKGROUND:The clinical presentation of malaria, considered as the result of a complex interaction between parasite and human genetics, is described to be different between rural and urban areas. The analysis of the Plasmodium falciparum genetic diversity in children with uncomplicated malaria, living in these two diff...

journal_title：Malaria journal

authors： Soulama I,Nébié I,Ouédraogo A,Gansane A,Diarra A,Tiono AB,Bougouma EC,Konaté AT,Kabré GB,Taylor WR,Sirima SB

更新日期：2009-06-20 00:00:00

abstract：BACKGROUND:Community distribution of anti-malarials and antibiotics has been recommended as a strategy to reduce the under-five mortality due to febrile illnesses in sub-Saharan Africa. However, drugs distributed in these interventions have been considered weak by some caretakers and utilization of community medicine d...

journal_title：Malaria journal

authors： Rutebemberwa E,Nsabagasani X,Pariyo G,Tomson G,Peterson S,Kallander K

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...

journal_title：Malaria journal

authors： Obbard DJ,Welch JJ,Little TJ

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing in India, although it is not included in the National Drug Policy for treatment of malaria. Efficacy...

journal_title：Malaria journal

authors： Valecha N,Srivastava P,Mohanty SS,Mittra P,Sharma SK,Tyagi PK,Pradhan K,Dev V,Singh R,Dash AP,Sharma YD

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified. Although TLR9 activation by malaria parasites is well reported, the implication to the susceptibility to severe malaria is not clear. The aim of this study ...

journal_title：Malaria journal

authors： Campino S,Forton J,Auburn S,Fry A,Diakite M,Richardson A,Hull J,Jallow M,Sisay-Joof F,Pinder M,Molyneux ME,Taylor TE,Rockett K,Clark TG,Kwiatkowski DP

更新日期：2009-03-13 00:00:00

abstract：BACKGROUND:Malaria is a global health emergency, and yet our understanding of the energy metabolism of the principle causative agent of this devastating disease, Plasmodium falciparum, remains rather basic. Glucose was shown to be an essential nutritional requirement nearly 100 years ago and since this original observa...

journal_title：Malaria journal

authors： Lian LY,Al-Helal M,Roslaini AM,Fisher N,Bray PG,Ward SA,Biagini GA

更新日期：2009-03-06 00:00:00

abstract：BACKGROUND:Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. METHODS:In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and level...

journal_title：Malaria journal

authors： Nyakoe NK,Taylor RP,Makumi JN,Waitumbi JN

更新日期：2009-01-09 00:00:00

abstract：:Monitoring and evaluation of malaria control in pregnancy is essential for assessing the efficacy and effectiveness of health interventions aimed at reducing the major burden of this disease on women living in endemic areas. Yet there is no currently integrated strategic approach on how this should be achieved. Malari...

journal_title：Malaria journal

authors： Brabin BJ,Warsame M,Uddenfeldt-Wort U,Dellicour S,Hill J,Gies S

更新日期：2008-12-11 00:00:00

abstract：BACKGROUND:Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS:Of 151 patients with presumed...

journal_title：Malaria journal

authors： Graz B,Dicko M,Willcox ML,Lambert B,Falquet J,Forster M,Giani S,Diakite C,Dembele EM,Diallo D,Barennes H

更新日期：2008-11-23 00:00:00

abstract：BACKGROUND:Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for trea...

journal_title：Malaria journal

authors： Sutherland CJ,Laundy M,Price N,Burke M,Fivelman QL,Pasvol G,Klein JL,Chiodini PL

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) is recommended for reducing the risk of malaria in pregnancy and its consequences on mothers and babies (IPTp-SP). Indicators of implementation and effects of IPTp-SP were collected in a rural clinic in Southern Senegal. METHODS:Women se...

journal_title：Malaria journal

authors： Olliaro PL,Delenne H,Cisse M,Badiane M,Olliaro A,Vaillant M,Brasseur P

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:Adequate malaria diagnosis and treatment remain major difficulties in rural sub-Saharan Africa. These issues deserve renewed attention in the light of first-line treatment with expensive artemisinin-combination therapy (ACT) and changing patterns of transmission intensity. This study describes diagnostic and...

journal_title：Malaria journal

authors： Mwanziva C,Shekalaghe S,Ndaro A,Mengerink B,Megiroo S,Mosha F,Sauerwein R,Drakeley C,Gosling R,Bousema T

更新日期：2008-11-05 00:00:00

abstract：BACKGROUND:Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. Such an assay could be used to distinguish recrudescence from re-infection in drug trials, to monitor...

journal_title：Malaria journal

authors： Daniels R,Volkman SK,Milner DA,Mahesh N,Neafsey DE,Park DJ,Rosen D,Angelino E,Sabeti PC,Wirth DF,Wiegand RC

更新日期：2008-10-29 00:00:00

abstract：BACKGROUND:The efficient allocation of financial resources for malaria control and the optimal distribution of appropriate interventions require accurate information on the geographic distribution of malaria risk and of the human populations it affects. Low population densities in rural areas and high population densit...

journal_title：Malaria journal

authors： Tatem AJ,Guerra CA,Kabaria CW,Noor AM,Hay SI

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:The use of artemisinin-based combination therapy (ACT) at the community level has been advocated as a means to increase access to effective antimalarial medicines by high risk groups living in underserved areas, mainly in sub-Saharan Africa. This strategy has been shown to be feasible and acceptable to the c...

journal_title：Malaria journal

authors： Ajayi IO,Browne EN,Bateganya F,Yar D,Happi C,Falade CO,Gbotosho GO,Yusuf B,Boateng S,Mugittu K,Cousens S,Nanyunja M,Pagnoni F

更新日期：2008-09-27 00:00:00